FIGURE 6.
Effect of Sj7170 on tumor growth in vivo. A, tumor volume curve of nude mice treated by Sj7170. After tumor cells were injected subcutaneously into male athymic nude mice, the short and long diameters of the tumors were measured every 3 days, and tumor volumes (cm3) were calculated. Tumor-bearing mice were then sacrificed after 32 days. B, photograph of representative tumors derived from control and Sj7170-treated cells in nude mice. C, comparison of tumor weights of nude mice treated and not treated by Sj7170. D, representative immunohistochemistry image of cyclin D1 expression in two xenograft tumor tissues. E, cyclin D1 expression of tumor tissue in both Sj7170-treated and -untreated groups. Western blot was used to detect the expression of cyclin D1. Lanes c and c represent the control group.