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. 2014 Mar 10;289(17):11681–11694. doi: 10.1074/jbc.M113.517581

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 8. — 1,25(OH)₂D₃ inhibits COX-2 expression by up-regulating THEM4 in RAW 264.7 cells. A, effect of 1,25(OH)₂D₃ on THEM4 expression in RAW264.7 cells. B, densitometric quantitation of THEM4 expression as shown in A. #, p < 0.05 versus nontreatment of 1,25(OH)₂D₃; n = 6. C, effect of VDR knockdown (si-VDR) on 1,25(OH)2D₃-mediated up-regulation of THEM4 in RAW 264.7 cells. D, densitometric quantitation of THEM4 expression as shown in C. #, p < 0.05 versus nontreatment of 1,25(OH)₂D₃; *, p < 0.05 versus treatment of scramble siRNA; n = 6. E, knockdown of THEM4 by specific siRNA (siRNA). *, p < 0.05; n = 3. F, effect of knocking down THEM4 on 1,25(OH)₂D₃-mediated inhibition of COX-2 expression and p-Akt in RAW264.7 cells. G, densitometric quantitation of COX-2 as shown in F. *, p < 0.05 versus LPS control; #, p < 0.05 versus nontreatment with 1,25(OH)₂D₃; &, p < 0.05 versus scramble siRNA; n = 6. H, densitometric quantitation of p-Akt as shown in F. *, p < 0.05 versus LPS control; #, p < 0.05 versus nontreatment with 1,25(OH)₂D₃; &, p < 0.05 versus scramble siRNA; n = 6. I, effect of 1,25(OH)2D₃ on cellular FFA production in RAW264.7 cells. *, p < 0.05; n = 6. Ctrl, control; Scram, scramble.