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. 2003 Aug 20;2003(3):164–169. doi: 10.1155/S1110724303208019

Figure 1.

Figure 1

Figure 1

Schematic representation of the main components present in the blastocyst and bone marrow microenvironment. (a) Preimplanted embryo (blastocyst) composed by the inner cell mass (ICM) and the trophectoderm cell layer (TE). Abbreviations: FGF2/FGF, fibroblast growth factor 2 and 1; FGFR-1, fibroblast growth factor receptor-1; LIF, leukemia inhibitory factor; LIFR, leukemia inhibitory factor receptor; JAK, JAK kinase; STAT, transcription factor STAT; STATa, transcription factor STAT activated. (b) Adult bone marrow composed by HSCs, hematopoietic stem cells; MSCs, mesenchymal stem cells; and other cellular components such as adipocytes, stromal cells, hematopoietic lineage, macrophages, dendritic cells, osteoblasts, and adipoblasts. In addition, it is composed also by extracellular matrix proteins such as types I and II collagen, tenascin, laminin, and the proteoglycan heparan sulphate. Abbreviations: SDF-1, stroma-derived factor-1; SCF, stem cell factor; CAM, cell adhesion molecule.