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PI-1833 and its potent analog PI-1840 are selective inhibitors for CT-L activity in vitro. A, chemical structures of PI-1833 and PI-1840 with their IC50 values against different proteasome activities. B, effects of PI-1840 and bortezomib on the CT-L activities of the 20 S constitutive rabbit proteasome and 20 S human immunoproteasome. Data are representative of at least two independent experiments.
