TABLE 2.

Effects of PI-1840, nutlin, and BH3-M6 on cancer cell viability

Upper panel, PI-1840 sensitizes HCT-116-p53^+/+ but not HCT-116-p53^−/− cells to nutlin-mediated inhibition of cell viability. The two HCT-116 cell lines were treated with either nutlin alone or in combination with PI-1840, and the effects on viability were determined by MTT as described under “Experimental Procedures.” Lower panel, PI-1840 sensitizes LNCaP but not DU-145 cells to BH3-M6-mediated inhibition of cell viability. LNCaP and DU145 cells were treated with either BH3-M6 alone or in combination with PI-1840, and the effects on viability were determined by MTT as described under “Experimental Procedures.”