FIGURE 5.

NRA-2 suppresses MEC-10(d)-induced currents in Xenopus oocytes. A and B, representative traces of Na⁺ current in Xenopus oocytes induced by expression of MEC channel subunits containing MEC-10(d) without NRA-2 (A) and with co-injection of NRA-2 (B). Voltage protocol was from −160 mV to + 100 mV from a holding potential of −30 mV. C, current amplitude histogram of Na⁺ current recorded at −100 mV in oocytes, with and without co-injection of NRA-2 (n = 9). **, p < 0.01, Student's t test. D, the percentage of current suppression of MEC-4(d) and/or MEC-10(d)-induced Na⁺ current by NRA-2 co-injection in oocytes. p values indicate significance of suppression over controls not injected with NRA-2, by Student's t test.