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. 2014 Feb 24;289(17):11916–11926. doi: 10.1074/jbc.M113.533695

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© 2014 by The American Society for Biochemistry and Molecular Biology, Inc.

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FIGURE 6. — A model of NRA-2 function in C. elegans TRNs. A working model of NRA-2 interaction with a mechanosensory channel composed of wild type and MEC-10(d) subunits is shown. Top, in the ER, NRA-2 functions to evaluate assembling MEC channel complexes, and mutant MEC-10(d)-containing channels are preferentially retained in the ER. Bottom, in an nra-2(Δ) background, there is relaxed retention of mutant MEC-10(d)-containing channels in the ER. Consequently, more MEC-10(D)-containing channels are trafficked to the surface, and the resulting accumulation and function of toxic channels lead to enhanced neurotoxicity.