FIGURE 3.

Differing extracellular turrets in domain II P-loop (exons 12a and 12b) do not alter major features outside of monovalent ion permeability. There were no major differences in most biophysical properties between LCa_v3-12a and LCa_v3-12b in 2 mm [Ca²⁺]_ex, including the following: A, current-voltage relationship for activation and steady-state inactivation; B, inactivation kinetics and time to peak (inset); C, current size differences in 2 mm [Ba²⁺]_ex versus [Ca²⁺]_ex, and D, blockade by 300 μm Ni²⁺. A sample of the blocking effect for nickel for LCa_v3-12a is shown in the inset of D. A sample of a similar block of nickel for LCa_v3-12b is shown in Fig. 3, A and B, of Ref. 13. There are measurable differences in faster recovery rate from inactivation (E) and slower deactivation kinetics for LCa_v3-12a (F). n values are shown in parentheses. The differences in the rate of recovery is observed at the earliest time point, when the time scale range is limited from 0 to 2 s (E, inset). Statistics for Fig. 3 are shown in Table 4.