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. 2014 Mar 13;289(17):11971–11985. doi: 10.1074/jbc.M114.547190

FIGURE 10.

FIGURE 10.

Loss-of-function of the NPC component Nup107 phenocopies the sec13sq198 retinal phenotype. A and B, WT embryo (A) and a nup107tsu068Gt mutant (nup107) embryo (B) at 84 hpf. Higher magnification of the eye image is shown on the right correspondingly. C and D, H&E staining analysis of the retina in the WT (C) and nup107tsu068Gt mutant (D) at 84 hpf. E and F, immunostaining of the NPCs in nuclear pores in WT (E) and nup107tsu068Gt mutant (F) at 84 hpf. G and H, mRNA export assay in the WT (G) and nup107tsu068Gt mutant (H) at 84 hpf. I–N, immunostaining of Zpr-1 in the WT (I–K) and nup107tsu068Gt mutant (L–N) retina at 84 hpf. L, lens. Scale bar, 300 μm (A and B), 150 μm (insets in A and B), and 50 μm (C, D, and I–N).