FIGURE 3.

ManR and ASGR mRNA levels increase in response to exogenous progesterone. Female and male mice were given a single intraperitoneal dose of 100 μg of progesterone in oil. Six days later, the mice were sacrificed, and the levels of message in the liver were determined by qPCR for A (ManR), B (Asgr-1), and C (Asgr-2). The steady state mRNA levels for female mice treated with progesterone (P4) increased 3-fold (p = 0.005) for the ManR, 4-fold (p = 0.004) for Asgr-1, and 7-fold (p = 0.003) for Asgr-2. Changes in message levels for male mice treated with progesterone were not significant. Significance was determined by unpaired t test analysis. Error bars are S.E. with n = 6.