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. 2014 Mar 26;57(8):3532–3545. doi: 10.1021/jm500268j

Scheme 1. Synthesis of Triaryl-Substituted Schiff Base Analogues 2 and 4 with the Improved Method.

Scheme 1

Reagents and conditions: (a) aniline derivatives (3 equiv), HCl(g), PhCl, 140–145 °C, 24 h; (b) KOH, MeOH, rt, 3 h; (c) resorcinol, AlCl3, sulfolane, 65–70 °C, 8 h.