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. 2014 Feb 28;114(8):4602–4620. doi: 10.1021/cr400432d

Figure 9.

Figure 9

Crystal structures of RNA demethylases: (A) Human FTO (PDB ID 3LFM), where the N-terminal AlkB-like domain (residues 32–326) and C-terminal domain (residues 327–498) are colored in blue and yellow, respectively; the extra loop for single-stranded substrate recognition is highlighted in red; iron(II) is shown in orange; and N-oxalylglycine (green) was used to substitute α-KG to afford a catalytically inert FTO. (B) Human ALKBH5 (PDB ID 4NJ4), where the AlkB-like domain is labeled in blue with the single-stranded substrate recognition loop labeled in red. Mn(II) (orange) replaces iron(II) in the structure.