Figure 5.

Vaccination with CpG adjuvant reduces HBV DNA in the liver. (a) AAV/HBV (2×10¹⁰ vg)-infected mice were treated with the indicated vaccine combinations. HBV DNA levels in the liver were determined by real-time PCR at 11 weeks post-vaccination. (b) HBsAg levels in the liver were measured by ELISA at 11 weeks post-vaccination with homogenized liver tissues. (c) Immunohistochemical staining of HBcAg in the liver sections of different groups (n=3). AAV, adeno-associated virus; HBcAg, HBV core antigen; HBsAg, HBV surface antigen; HBV, hepatitis B virus.