Figure 1.

The structure and main domains of TIM gene family members. The sequences (a) and schematic structures (b) are shown for each TIM gene family member. TIM molecules are type-I cell-surface glycoproteins that comprise an extracellular IgV domain, a mucin-like domain, a transmembrane domain and an intracellular cytoplasmic tail. All TIM molecules have a conserved sequence homology in the IgV domains, while other domains show little similarity. The sequence data were generated using the PRALINE multiple sequence alignment function. TIM, T-cell immunoglobulin mucin.