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Concentration-time curves of ritonavir (RTV) in the hepatic portal vein. The rats were intragastrically administered a single dose of 20(S)-ginsenoside Rh2 (Rh2) (25 mg/kg), GF120918 (5 mg/kg), or intragastric vehicle (0.5% CMC-Na) 1 h before the oral administration of RTV (25 mg/kg, po) or were intravenously injected with a single dose of Rh2 (5 mg/kg) 30 min before receiving RTV (25 mg/kg, po). Each value represents the mean±SEM (n=5).
