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. 2013 Aug 26;34(10):1337–1348. doi: 10.1038/aps.2013.86

Table 4. Plasma pharmacokinetics of borneol, isoborneol, and camphor in rats receiving Bingpian, synthetic Bingpian, or Fufang-Danshen tablets. The data are expressed as the mean±standard deviation (relative standard deviation).

Compound Cmax or C5 min (nmol/L) Tpeak (h) AUC0–t (h·nmol/L) AUC0–∞ (h·nmol/L) (h) t1/2–(1) (h) t1/2–(2) (h) MRT (h) CLtot, p (L·h−1·kg−1) VSS (L/kg) F (%)
Natural Bingpian at an oral dose of 20 mg borneol/kg
Borneol 116±39 0.083±0 1266±307 1558±413 10.6±0.8 11.6±2.8
Camphor 108±50 0.083±0 362±24 432±106 6.1±1.8
Natural Bingpian at an intravenous dose of 5 mg borneol/kg
Borneol 5122±1030 2724±517 2825±583 0.7±0.1 8.5±2.0 2.5±0.8 12.3±2.5 40.2±12.0
Camphor 149±17 207±77 210±78 1.3±0.5 1.6±0.5
Synthetic Bingpian at an oral dose of 20 mg borneol+isoborneol/kg
Borneol 201±114 0.083±0 1209±105 1726±354 11.3±0.3 12.7±1.1
Isoborneol 84±34 0.39±0.53 310±140 331±135 10.4±3.0 8.7±3.9
Camphor 354±15 0.14±0.10 1311±461 1471±547 8.8±1.2
Synthetic Bingpian at an intravenous dose of 5 mg borneol+isoborneol/kg
Borneol 3691±374 2375±230 2576±265 0.8±0.1 8.0±2.9 3.6±0.7 8.6±0.9 50.7±16.9
Isoborneol 2113±141 893±83 902±74 1.0±0.1 0.9±0.2 13.7±1.4 13.0±1.3
Camphor 349±24 984±172 1011±161 2.5±3.1 4.1±0.7
Fufang-danshen tablets at an oral dose of 20 mg borneol+isoborneol/kg
Borneol 109±24 1.39±2.26 1349±327 1612±262 12.0±1.2 14.2±3.4
Isoborneol 35±21 1.39±2.26 101±64 105±71 5.3±2.4 2.8±1.8
Camphor 201±160 2.69±2.26 1128±297 1456±589 7.8±1.2

Cmax, maximum plasma concentration after oral dose; C5 min, plasma concentration at 5 min after intravenous dose; Tpeak, time taken to achieve peak concentration; t1/2, elimination half-life; AUC0←t, area under concentration-time curve up to the time of last measurable concentration; AUC0←∞, AUC0←t extrapolated to infinity; MRT, mean residence time; CLtot,p, total plasma clearance; VSS, distribution volume at steady state.