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. 2014 Mar 31;11:7. doi: 10.1186/2045-8118-11-7

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Copyright © 2014 Guerra; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly credited. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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A representation of normal cortical development showing the timed disruption of the ventricular zone in mouse (red arrow). The phenotype of cells located in the ventricular zone (VZ) changes during normal brain development. Cell-cell junction pathology in the radial glial/neural stem cells and ependyma leads to the disruption of the VZ. In mouse, the exposure of the neural progenitor cells (NPC) localized in the subventricular zone (SVZ) occurs from embryonic day (E) 12.5 onward, when neurogenesis has been initiated. Note that the VZ cells contact the cerebrospinal fluid (CSF) during embryonic development. A timeline comparing neurogenesis events in the cortex of the mouse and rat in embryonic days (E) and in human with gestational age in weeks (GA) has been drawn, using a statistical model developed for Clancy et al.[68,69]. PN, postnatal; As, astrocytes.