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. 2014 Mar 20;2(3):e00257. doi: 10.1002/phy2.257

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Ascending aorta inner diameter (ASID) (A) increases with age and is affected by genotype. The percent increase of the ASID (B) is reduced in Fbln5−/− mice at all ages. The distensibility of the ascending aorta (C) is reduced in Fbln5−/− mice at P21 and P60. Distensibility cannot be calculated at P7, because we cannot measure arterial pulse pressures at this age. Carotid artery inner diameter (CAID) (D) increases with age and is affected by genotype. The percent increase of the CAID (E) is reduced in Fbln5−/− mice at P21 and P60. The distensibility of the carotid artery (F) is reduced in Fbln5−/− mice at P21 and P60. *P < 0.05 between genotypes. n = 10–22 per group.