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. 2014 Mar 20;2(3):e00257. doi: 10.1002/phy2.257

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© 2014 The Authors. Physiological Reports published by Wiley Periodicals, Inc. on behalf of the American Physiological Society and The Physiological Society.

This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

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Representative Doppler images (A) with mitral valve (MV) early (E) and atrial (A) peak velocity values, and measurements of isovolumic relaxation times (IVRT) and deceleration times (DT) in P60 wild‐type (WT) and Fbln5−/− mice. MV E (B) is affected by age, but not genotype. MV A (C) is affected by genotype, but not age. The E/A ratio (D), a measure of diastolic function, is affected by age and genotype. DT (E) and IVRT (F) are increased in Fbln5−/−mice at P21. *P < 0.05 between genotypes. n = 10–22 per group.