Table 1.

Results of the GLM for each variable including independent effects of age, sex, and genotype (GT) and interactions between the independent variables. Significant values (P < 0.05) and good fits to the GLM (R ² > 0.7) are shown in bold. Two‐tailed t‐tests with unequal variance were performed to compare genotypes at each age when genotype or genotype*age had a significant effect in the GLM. Definitions for each variable are given in the footnote below

Variable	Age	Sex	GT	Age*Sex	GT*Sex	GT*Age	GT*Age*Sex	R 2
SP	0.000	0.147	0.154	0.000	0.001	0.007	0.000	0.872
DP	0.000	0.215	0.000	0.024	0.003	0.255	0.001	0.652
PP	0.364	0.102	0.000	0.000	0.188	0.038	0.340	0.627
BW	0.000	0.000	0.003	0.000	0.767	0.003	0.484	0.967
LVM	0.000	0.378	0.003	0.071	0.436	0.170	0.908	0.889
LVM/BW	0.000	0.130	0.001	0.313	0.619	0.181	0.985	0.397
LVIDdias	0.000	0.938	0.547	0.035	0.742	0.599	0.692	0.941
LVIDsys	0.000	0.472	0.710	0.293	0.453	0.668	0.830	0.838
FS	0.000	0.155	0.430	0.414	0.205	0.469	0.512	0.480
LVVd	0.000	0.032	0.392	0.011	0.688	0.384	0.352	0.924
LVVs	0.000	0.042	0.219	0.139	0.951	0.389	0.984	0.825
SV	0.000	0.473	0.763	0.138	0.627	0.847	0.220	0.831
EF	0.001	0.662	0.566	0.330	0.809	0.284	0.555	0.301
ASIDdias	0.000	0.669	0.014	0.532	0.269	0.257	0.429	0.857
ASIDsys	0.000	0.268	0.000	0.596	0.691	0.003	0.960	0.883
ASID%inc	0.005	0.254	0.000	0.349	0.352	0.004	0.036	0.590
CAIDdias	0.000	0.237	0.007	0.028	0.309	0.137	0.403	0.731
CAIDsys	0.000	0.467	0.000	0.370	0.055	0.001	0.760	0.933
CAID%inc	0.000	0.133	0.000	0.214	0.264	0.084	0.825	0.502
AVDs	0.000	0.448	0.348	0.811	0.043	0.303	0.066	0.861
HR	0.000	0.945	0.175	0.809	0.203	0.054	0.919	0.444
CO	0.000	0.248	0.938	0.187	0.165	0.896	0.380	0.596
CO/BW	0.642	0.592	0.651	0.186	0.044	0.533	0.712	0.130
E	0.002	0.487	0.654	0.348	0.731	0.306	0.460	0.209
A	0.196	0.445	0.021	0.445	0.544	0.009	0.141	0.270
E/A	0.000	0.997	0.001	0.729	0.776	0.157	0.657	0.325
DT	0.087	0.131	0.180	0.474	0.044	0.066	0.034	0.275
IVRT	0.612	0.853	0.090	0.548	0.939	0.497	0.819	0.096
E’	0.004	0.053	0.000	0.817	0.201	0.974	0.572	0.347
S’	0.062	0.117	0.524	0.012	0.174	0.312	0.697	0.233
A’	0.020	0.213	0.001	0.237	0.200	0.025	0.902	0.332
E’/A’	0.000	0.203	0.000	0.338	0.022	0.008	0.648	0.627
E/E’	0.398	0.142	0.000	0.252	0.711	0.052	0.170	0.317
Collagen	0.001	N/A	0.326	N/A	N/A	0.043	N/A	0.483
Elastin	0.585	N/A	0.585	N/A	N/A	0.899	N/A	0.127

GLM, general linear model; SP, systolic pressure; DP, diastolic pressure; PP, pulse pressure; BW, body weight; LVM, left ventricular (LV) mass; LVM/BW, LV mass normalized to body weight; LVIDdias, LV inner diameter at diastole; LVIDsys, LV inner diameter at systole; FS, fractional shortening; LVVd, LV volume at diastole; LVVs, LV volume at systole; SV, stroke volume; EF, ejection fraction; ASIDdias, ascending aortic inner diameter at diastole; ASIDsys, ascending aortic inner diameter at systole; ASID%inc, percent increase of the ascending aorta from diastole to systole; CAIDdias, carotid artery inner diameter at diastole; CAIDsys, carotid artery inner diameter at systole; CAID%inc, percent increase of the carotid artery from diastole to systole; AVDs, aortic valve diameter at systole; HR, heart rate; CO, cardiac output; CO/BW, cardiac output normalized to body weight; E, peak velocity of the early filling wave through the mitral valve; A, peak velocity of the atrial filling wave through the mitral valve; E/A, ratio of the early to atrial filling wave velocities; DT, deceleration time of the early filling velocity; IVRT, isovolumic relaxation time; E’, peak velocity of the LV lateral wall during early filling; S’, peak velocity of the LV lateral wall during systole; A’, peak velocity of the LV lateral wall during atrial filling; E’/A’, ratio of the LV wall velocities during early and atrial filling; E/E’, ratio of the wave velocity to the LV wall velocity during early filling; Collagen, normalized LV collagen content; Elastin, normalized LV elastin content.