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Increased NADPH oxidase activity and superoxide production in ACE2‐deficient mice. (A) Kidney NADPH oxidase activity was significantly increased in ACE2 KO mice as determined by repeated measures general linear model analysis. (B) NADPH oxidase activity expressed as normalized percent of WT control (***P < 0.001). (C) Nox4 subunit mRNA expression measured by RT‐qPCR in a different group of mice was twofold increased in ACE2KO mice as compared to WT controls (*P < 0.01).
