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Increased markers of oxidative stress. (A) Kidney cortex H2O2 release in ACE2 KO mice (n = 6) was significantly higher as compared to WT control (n = 10) (20.2 ± 4 vs. 8.41 ± 3 μmol/L/mg/min ***P < 0.01). (B) Twenty‐four‐hour Urinary 8‐Isoprostane excretion was higher in ACE2 KO mice compared to WT littermates (2939.8 ± 532 vs. 1603.3 ± 186 pg/24 h; **P < 0.05, n = 5 ACE2 KO, n = 7 WT).
