K562-r cells were exposed to berbamine at 21.2 μmol/L for different time periods and Bcl-2, Bax, Bcl-xL, PARP, total cyt C, cytoplasmic cyt C, and P-glycoprotein levels (A, B, C, D, E,) were determined by Western blot. mdr-1 mRNA levels (F) were determined by RT-PCR. β-actin was used as a loading control.