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. 2012 Aug 27;9(5):390–398. doi: 10.1038/cmi.2012.28

Figure 2.

Figure 2

The effect of SAHA on the expressions of inflammatory cytokines and immunomolecules. (a–f) The allografts were harvested 7 days after transplantation and were homogenized. Foxp3, CTLA-4, IL-17, CD11b, IL-10 and IFN-γ mRNA were measured by qPCR. The data are expressed as mean±s.d. (n=3). *P<0.05, **P<0.01, compared with DMSO group. NC, negative control represented cardiac graft from isotransplantation. (g–h) The recipient thymus, draining lymph nodes and spleens were harvested 7 days after transplantation. CD4+ T cells were isolated and CD25+ and Foxp3+ T cells were measured by flow cytometry. Shown are representative of three separate experiments. DMSO, dimethylsulfoxide; FK, tacrolimus; IFN, interferon; qPCR, quantitative PCR; SAHA, suberoylanilide hydroxamic acid.