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. Author manuscript; available in PMC: 2015 Mar 1.

Published in final edited form as: Clin Lung Cancer. 2013 Nov 15;15(2):119–123. doi: 10.1016/j.cllc.2013.11.007

Table 3.

Toxicity profile

Toxicity	Cohort (1) (N=4)			Cohort (−1) (N=6)
Toxicity	Any grade	Grade 3	Grade 4	Any grade	Grade 3	Grade 4
Cardiovascular	3			1
Constitutional	3		1^*^{^}	3
Gastrointestinal	2	1		5
Lymphopenia	1		1^*^{^}	2	2
Neutropenia				2
Decreased platelet count	1			2
Other hematological	1			2	1
Infection	2				1
Metabolic/Laboratory	3			3	2
Pain		2		4
Pulmonary	2	1^*^{^}		2	1^*
Neurologic	2			4
Dermatologic	1			3
Hemorrhage/ Thromboembolic		1		1	2
Sudden Death	1^*

^*

Dose limiting toxicities

^{^}

This patient developed all of the following: grade 3 pneumonitis, grade 4 fatigue and grade 4 lymphopenia.