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. 2013 Aug 19;10(6):490–496. doi: 10.1038/cmi.2013.33

Figure 1.

Figure 1

The scheme for full screening of HLA-A*02 alleles from haploid genomes using group-specific amplification. In Main-screening1, the reactions 78C/I3 and 78T/I3 amplify HLA-A alleles of General Non-A*02 (GNA2) and General A*02 (GA2) groups, respectively; the remaining HLA-A alleles are grouped as Special HLA-A (SA), in which reaction 77G/538A discriminates A*02:236 from Exceptional Non-A*02 (ENA2) alleles through Main-screening2. Reaction 318A/555A discriminates Special A*02 (SA2) alleles from Non-A*02 (NA2) alleles in GNA2 group through Sub-screening1, and either 149C/440G or 412A/555G or both reactions indicate the presence of Special Non-A*02 (SNA2) other than A*02 (A2) alleles in the GA2 group via Sub-screening2. The reactions are detailed in Table 3.