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. 2009 Mar 5;30(3):346–354. doi: 10.1038/aps.2009.3

Table 1. Cytotoxicity and resistance factors of GA3 and reference drug DOX in MDR and drug-sensitive parental cell lines.

 
  
 IC50 (mean±SD) (μmol/L)
  
  
  
 RF
Drug K562 K562/A02 MCF7 MCF7/ADR K562/A02 MCF7/ADR    
GA3
 6.08±2.09
 8.88±0.35
 5.55±0.64
 25.40±0.57
 1.46
 4.58
DOX 0.43±0.17 23.81±2.99 0.39±0.12 44.90±1.27 55.93 114.25

IC50 values were determined from 3 separate experiments; each drug concentration was tested in triplicate. The resistance factor (RF) was calculated as the ratio of the IC50 value of the MDR cells to that of corresponding sensitive parental cells.