Table 2. Pharmacokinetic parameters of CTLA4Ig after a single intravenous infusion at a dose of 1, 10, and 20 mg/kg. n=9. Data are expressed as means±SD. bP<0.05, cP<0.01 vs 1 mg/kg group (Student's t-test). eP<0.05, fP<0.01 vs 10 mg/kg group (Student's t-test). AUC0–Z represents observed AUC from 0 to 84 d after infusion.
| Parameters | 1 mg/kg | 10 mg/kg | 20 mg/kg | P |
|---|---|---|---|---|
| AUC(0–z)/mg·d·L−1 | 170±27 | 1490±231c | 2977±362cf | <0.001 (K-W H test) |
| AUC(0–∞)/ mg·d·L−1 | 175±29 | 1522±232c | 3014±365cf | <0.001 (K-W H test) |
| AUC(0–z)/dose | 171±28 | 149±23 | 149±18 | 0.094 (ANOVA) |
| AUC(0–∞)/dose | 175±29 | 152±23 | 151±18 | 0.067 (ANOVA) |
| MRT/d | 19.9±2.1 | 19.6±1.8 | 18.8±0.9 | 0.326 (ANOVA) |
| Cl/L·d−1·kg−1 | 0.0058±0.0010 | 0.0067±0.0010 | 0.0067±0.0008 | 0.119 (ANOVA) |
| Vss/L·kg−1 | 0.126±0.022 | 0.138±0.033 | 0.114±0.016 | 0.143 (ANOVA) |
| t1/2/d | 15.1±2.6 | 14.2±2.3 | 11.8±1.2be | 0.08 (ANOVA) |
| Ke/d−1 | 0.102±0.013 | 0.146±0.012 | 0.147±0.012 | 0.069 (ANOVA) |
| Cmax/mg·L−1 | 18.4±1.6 | 186.9±24.7b | 416.8±34.4ce | <0.001 (K-W H test) |
| Tmax/d | 0.0416±0 | 0.0416±0 | 0.0416±0 | >0.05 (K-W H test) |