. 2009 Mar 5;30(3):364–371. doi: 10.1038/aps.2009.13

Table 4. Pharmacokinetic parameters of CTLA4Ig after multiple intravenous infusions of 10 mg/kg in patients with rheumatoid arthritis (n=8). AUC_0–Z represents observed AUC_{0-84 d} after the last dose at steady state.

Parameters	AUC_(0–z) (mg·d·L⁻¹)	AUC_(0–∞) (mg·d·L⁻¹	MRT (d)	Cl (L·d⁻¹·kg⁻¹)	V_ss (L·kg⁻¹)	t_1/2 (d)	K_e (d⁻¹)	C_max (mg·L⁻¹)	T_max (d)
1	1166	1168	12.0	0.0086	0.121	9.99	0.069	181.9	0.042
2	2186	2195	16.2	0.0046	0.066	4.35	0.159	258.8	0.125
3	3340	3361	18.2	0.0030	0.045	12.9	0.054	291.4	0.042
4	2417	2435	17.6	0.0041	0.066	14.9	0.047	288.7	0.042
5	2712	2743	19.3	0.0036	0.062	20.9	0.033	303.1	0.042
6	2173	2199	19.2	0.0045	0.077	13.6	0.051	217.3	0.125
7	3636	3646	14.4	0.0027	0.038	11.3	0.061	261.9	0.042
8	1147	1152	15.9	0.0087	0.120	13.1	0.053	173.5	0.042
Mean	2347	2362	16.6	0.0050	0.074	12.6	0.066	247.1	0.063
SD	901	906	2.5	0.0023	0.031	4.7	0.039	50.3	0.039

Table 4. Pharmacokinetic parameters of CTLA4Ig after multiple intravenous infusions of 10 mg/kg in patients with rheumatoid arthritis (n=8). AUC0–Z represents observed AUC0-84 d after the last dose at steady state.