Table 5. Comparison of pharmacokinetic parameters of CTLA4Ig at a dose of 10 mg/kg in healthy adult volunteers and patients with rheumatoid arthritis.

	Healthy volunteers	RA patients
Parameters	(after 10 mg/kg single dose)	(after 10 mg/kg multiple dosesa)	P value
	n=9	n=8
Cmax/mg·L−1	186.9±24.7	247.1±50.3	0.006 (t-test)
t1/2 (d)	14.2±2.3	12.6±4.7	0.385 (t-test)
Cl/L·d−1·kg−1	0.0067±0.0010	0.0050±0.0023	0.062 (t-test)
Vss/L·kg−1	0.138±0.033	0.074±0.031	0.001 (t-test)