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Chemical structure of the two oxime drugs. (A) HI-6, [1-(2-hydroxy-iminomethylpyridinium)-1-(4-carboxyamino)-pyridinium dimethylether]. and (B) Ortho-7, [1,7-heptylene-bis-N,N'-2-pyridiniumaldoxime]. The carbon, nitrogen, and oxygen atoms are numbered for referral purpose. The two pyridinium rings, one directed towards the active triad region and one directed towards the PAS region of the AChE enzyme, are indicated.
