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. 2010 Feb 8;31(3):313–328. doi: 10.1038/aps.2009.193

Figure 8.

Figure 8

Time-dependent minimal distance between the (A) peripheral pyridinium ring of Ortho-7 and the PAS residues, Tyr 72 (grey line) and Trp 286 (black line), (B) active-site pyridinium ring of Ortho-7 and the phenyl ring of Tyr 337 (grey line) and the indole ring of Trp 86 (black line), (C) peripheral pyridinium ring (carboxylamide-pyridinium) of HI-6 and the PAS residues, Tyr 124 (grey line) and Trp 286 (black line), and (D) active-site pyridinium ring of HI-6 and Tyr 337 (grey line) and Phe 338 (black line) during the process of the drugs leaving the active-site gorge of mAChE.