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Schematic representation of the effects and modes of action of CY, MTX and Cis. AICAR, aminoimidazole carboxamide ribonucleotide; CA, condylomata acuminata; Cis, cisplatin; CLP, cecal ligation and puncture; CY, cyclophosphamide; HMGB1, high-mobility group box 1 protein; MMP2, matrix metallopeptidase 2; MTX, methotrexate; NPC, nasopharygeal carcinoma; RA, rheumatoid arthritis; Treg, regulatory T; VEGF, vascular endothelial growth factor.
