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. 2011 Mar 21;8(4):341–347. doi: 10.1038/cmi.2011.7

Figure 3.

Figure 3

Phenotypic expression of DC maturation markers in response to different TLR agonists in combination with IFN. iDCs were matured with poly(I:C), LPS or both in the presence or absence of IFN-α and/or IFN-γ. The expression of CD83, CD38, CCR7 and CD74 was analyzed by flow cytometry. The combination of poly(I:C) and LPS with type I and II IFN upregulated the expression of CD83, CD38 and CCR7, but downregulated the expression of CD74 compared with DCs matured with other stimuli. Data are shown as the increase in MFI over the isotype control±s.d. from five independent experiments (*P<0.05; **P<0.02). DC, dendritic cell; iDC, immature DC; IFN, interferon; LPS, lipopolysaccharide; MFI, mean fluorescence intensity.