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. 2011 Mar 21;8(4):341–347. doi: 10.1038/cmi.2011.7

Figure 5.

Figure 5

IL-12p70 production after DC maturation with different TLR agonists in combination with IFN. iDCs underwent maturation for 48 h, as described in Figure 3. IL-12p70 secretion was measured in culture supernatants (left panel) and from DCs further stimulated with CD40L-transfected J558 cells (right panel). The addition of IFN-α and/or IFN-γ to TLR agonist stimulation enhanced IL-12p70 production during maturation as well as after CD40L stimulation. The data are shown as mean±s.d. (pg/ml) of triplicate cultures from three representative data sets from five independent experiments (*P<0.05; **P<0.02). CD40L, CD40 ligand; DC, dendritic cell; iDC, immature DC; IFN, interferon; LPS, lipopolysaccharide; TLR, Toll-like receptor.