Figure 6.

Migration of TLR agonist-stimulated DCs was enhanced in the presence of both type I and II IFNs. Immature DCs underwent maturation with different TLR agonists in combination with IFN and were tested for migration in response to CCL21 as a ligand for CCR7 in a transwell assay. The addition of IFN-α and IFN-γ to the TLR agonist combination markedly enhanced the migration of DCs. The results represent the mean number of migrated cells±s.d. from three independent experiments (*P<0.05). DC, dendritic cell; IFN, interferon; LPS, lipopolysaccharide; TLR, Toll-like receptor.