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. 2009 Jan 19;30(2):166–174. doi: 10.1038/aps.2008.23

Figure 1.

Figure 1

Effects of Tet on INa density in the SR myocytes of humans. (A) Current traces were obtained by a holding potential of −120 mV and a series of 5 mV depolarizing steps to voltages from −90 to 0 mV in the absence of Tet. (B) Original sodium current in the presence of 80 μmol/L Tet. (C) Original sodium current in the presence of 100 μmol/L Tet. (D) I–V relation curves of INa densities before and after the application of 80 μmol/L (n=10, P<0.01) and 100 μmol/L (n=8, P<0.01) Tet. (F) The effects of Tet on voltage-dependent activation curves of sodium current in SR cells; the data were fitted with a Boltzmann equation. The V1/2 was as follows: control, −50.1±0.5 mV, 80 μmol/L Tet, −45.9±0.2 mV (n=10, P<0.05 vs control), 100 μmol/L Tet, −41.3±0.3 mV (n=8, P<0.01 vs control). TP: test potential.