Table 2. The effects of Tet on INa density in SR and AF atrial myocytes. Mean±SEM. cP <0.01 vs control.
Maximal INa density (pA/pF) | |||||||
---|---|---|---|---|---|---|---|
CTet | 0 μmol/L | 40 μmol/L | 60 μmol/L | 80 μmol/L | 100 μmol/L | 120 μmol/L | Wash out |
SR | −58.6±7.8 | −53.3±8.5 | −42.1±6.9c | −31.3±6.2c | −18.9±5.7c | −7.3±2.6c | −49.6±10.8 |
(n=26) | (n=10) | (n=12) | (n=10) | (n=8) | (n=8) | (n=5) | |
AF | −61.8±8.8 | 52.7±9.5 | −43.4±7.1c | −34.4±6.0c | −13.7±4.3c | −5.2±2.2c | −53.7±11.8 |
(n=19) | (n=8) | (n=10) | (n=8) | (n=7) | (n=7) | (n=4) |
SR: sinus rhythm. AF: atrial fibrillation. CTet: concentration of tetrandrine.