Table 1. Uterine index and serum E2, FSH, and LH levels in E2- or ICS-treated rats. Results are means±SEM. n=8 rats/group. bP<0.05, cP<0.01 vs Sham-Veh group. eP<0.05, fP<0.01 vs OVX-Veh group.
Treatment | Uterine index (mg/g×100) | Level in serum |
||
---|---|---|---|---|
17β-Estradiol (pg/mL) | FSH (mIU/mL) | LH (mIU/mL) | ||
Sham-Veh | 287.0±16.0 | 24.5±1.9 | 1.8±0.2 | 1.2±0.2 |
OVX-Veh | 136.7±12.0c | 13.1±0.8c | 3.3±0.3c | 2.9±0.1c |
OVX+E2 | 196.3±71.0f | 22.1±0.5e | 2.2±0.5e | 1.3±0.1e |
OVX+ICS-20 | 150.8±27.6 | 17.6±0.7 | 2.6±0.3 | 2.4±0.3 |
OVX+ICS-50 | 180.1±21.4e | 18.5±1.6e | 2.5±0.4e | 2.2±0.4e |
OVX+ICS-100 | 186.1±11.3e | 19.4±1.1e | 2.4±0.6e | 1.5±0.1f |
Sham-Veh: Sham operated and vehicle treated group; OVX-Veh: Ovariectomized and vehicle treated group; OVX+E2: OVX and E2 (0.25 mg·kg−1·d−1, ig) treated group; OVX+ICS-20; OVX and ICS (20 mg·kg−1·d−1, ig) treated group; OVX+ICS-50: OVX and ICS (50 mg·kg−1·d−1, ig) treated group; and OVX+ICS-100: OVX and ICS (100 mg·kg−1·d−1, ig) treated group.