Skip to main content
. Author manuscript; available in PMC: 2014 Jul 1.
Published in final edited form as: Nat Rev Microbiol. 2013 Dec 2;12(1):23–34. doi: 10.1038/nrmicro3140

Figure 4. Arming strategies that induce bystander cell killing.

Figure 4

a | Convertase enzymes that are expressed in infected cells metabolize prodrugs into toxic metabolites that diffuse and kill uninfected tumour cells. b | The sodium–iodide symporter (NIS) concentrates radioactive ions in infected cells, which induces radiation poisoning of uninfected bystander tumour cells. c | Immunostimulatory transgenes that are expressed in infected cells prime responses against tumour antigens, which causes the systemic destruction of tumour cells.