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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: J Immunol. 2014 Mar 31;192(9):4303–4315. doi: 10.4049/jimmunol.1302244

Figure 3. Anti-viral CD8 responses are compromised by activation of plasma membrane TLRs.

Figure 3

(A) Mice that received OT-I CD8 T cells were infected using VSV-OVA or VSV-OVA mixed with different TLR ligands or live/heat killed Salmonella typhimurium (Sal/Sal-HK) and draining lymph nodes and the spleen were harvested on day 7 after infection to measure OT-I CD8 T cell expansion. (A, C, E). Representative plots show CD8 T cells that express GFP and stain positive for Kb-SIINFEKL tetramer. (B, D, F). Mean ± SEM of GFP-OT-I T cells as a percentage of total CD8 T cells from 5 independent mice per group. The data are representative of three (A, B, C and D) or two independent experiments (E and F). *, P < 0.05; **, P < 0.01; ***, P < 0.005.