Table 2.
Histologic and Radiologic Features of Resected pancreatic Neuroendocrine Neoplasms in 24 Patients with Von Hippel-Lindau
| All patients | Patients with MCAs+concurrent PNENs (n=5¶) | PNENs only (n=19) | |
|---|---|---|---|
| Patients with resection for solid tumors; n (% of resected) | 24 (100) | 5 (20.8) | 19 (79.2) |
| Age at operation, y, median (range) | 47 (24-71) | 48 (33-56) | 47 (24-71) |
| Resection performed, n* | 25 | 6 | 19 |
| Total pancreatectomy | 3 | 1 | 2 |
| Pancreaticoduodenectomy | 7 | 1 | 6 |
| Distal pancreatectomy | 8 | 3 | 5 |
| Enucleation | 7 | 1 | 6 |
| FDG-PET uptake; mean ±SD (range) | 10.3 ±6.2 (0-25) | 4.5 ±4.0 (0-10.4) | 12.2 ±5.7 (3.5-25)† |
| Size of tumor lesion, cm, mean ±SD (range)‡ | 2.30 ±1.51 (0-7) | 1.72 ±2.22 (0-6) | 2.45 ±1.29 (1.3-7) |
| PNEN staging; n/no. evaluable (% of group)§ | |||
| T1, ≤2 cm | 3/4 (75) | 7/19 (37) | |
| T2, limited to pancreas >2 cm | 1/4 (25) | 10/19 (53 | |
| T3, beyond pancreas, no involvement of SMA and celiac | 0 | 2/19 (11%) | |
| T4, beyond pancreas with involvement of SMA and celiac | |||
| N1 | 1/5(20) | 6/19(32) | |
| M1; n (%) | 0 | 2/19(11) | |
| Grade, n (%) | |||
| 1 | 2/4 (50) | 11/19 (58) | |
| 2 | 2/4 (50) | 8/19 (42) | |
*
One patient had more than one procedure performed, thus the number of resections is greater than the number of patients.
†
n=17.
‡
Largest PNEN size on final pathology.
§
TNM stage according to the American Joint Committee on Cancer 28, 29 and the World Health Organization histologic classification for PNEN (1 low grade NEN; 2 intermediate NEN; 3 high grade NEC).30
¶
Overall 5 patients with MCAs, 1 patient MCA only, 4 concurrent MCA+PNENs FDG, 18-Fluorodeoxyglucose; PNENs, pancreatic neuroendocrine neoplasms; SMA, superior mesenteric artery; VHL, Von Hippel-Lindau.