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Tiron altered the expression of apoptosis-related proteins. Western blot analysis revealed that MG-132 induced down-regulation of anti-apoptotic proteins Bcl-2 and XIAP, up-regulated expression of pro-apoptotic protein Bax and caspase-3, and produced cleaved C-terminal 85 kDa PARP. Additionally, tiron reversed these alterations. cP<0.01 vs control; fP<0.01 vs MG-132 group.
