Table 1.
Characteristics of study participants diagnosed with cardiovascular disease
|
Characteristics |
Death |
Re-hospitalization for cardiovascular disease |
||||||
|---|---|---|---|---|---|---|---|---|
| |
CVD* cohort |
AMI** cohort |
CVD* cohort |
AMI** cohort |
||||
| Number (%) | Number (%) | Number (%) | Number (%) | |||||
|
Total
|
2219 |
|
673 |
|
2285 |
|
695 |
|
|
Men |
1227 |
55% |
365 |
54% |
1269 |
56% |
374 |
54% |
|
Women |
992 |
45% |
308 |
46% |
1016 |
44% |
321 |
46% |
|
Age group, years
|
|
|
|
|
|
|
|
|
|
<65 |
291 |
13% |
57 |
8% |
303 |
13% |
62 |
9% |
|
65-75 |
425 |
19% |
95 |
14% |
446 |
20% |
98 |
14% |
|
75-85 |
844 |
38% |
280 |
42% |
872 |
38% |
292 |
42% |
|
> = 85 |
659 |
30% |
241 |
36% |
664 |
29% |
243 |
35% |
|
Upper gastrointestinal bleeding
|
|
|
|
|
|
|
|
|
| I. Bleeding before entry |
1730 |
78% |
513 |
76% |
1773 |
78% |
527 |
76% |
| II. Bleeding before entry and during the follow up |
49 |
2% |
22 |
3% |
44 |
2% |
20 |
3% |
| III. New bleeding during the follow up period |
86 |
4% |
41 |
6% |
71 |
3% |
33 |
5% |
| IV. Bleeding after endpoints |
354 |
16% |
97 |
14% |
397 |
17% |
115 |
17% |
|
Cardiovascular disease history
|
|
|
|
|
|
|
|
|
|
No |
1315 |
59% |
456 |
68% |
1361 |
60% |
475 |
68% |
|
Yes |
904 |
41% |
217 |
32% |
924 |
40% |
220 |
32% |
|
Comorbidities (number)
|
|
|
|
|
|
|
|
|
|
0 |
1382 |
62% |
328 |
49% |
1426 |
62% |
340 |
49% |
|
1 |
628 |
28% |
244 |
36% |
643 |
28% |
250 |
36% |
|
2 |
173 |
8% |
81 |
12% |
178 |
8% |
85 |
12% |
|
≥3 |
36 |
2% |
20 |
3% |
38 |
2% |
20 |
3% |
|
Drug exposure
|
|
|
|
|
|
|
|
|
|
Current clopidogrel and PPIs§ |
309 |
14% |
95 |
14% |
403 |
18% |
116 |
17% |
|
No current PPIs or clopidogrel |
861 |
39% |
211 |
31% |
905 |
40% |
226 |
33% |
|
Current only PPIs |
847 |
38% |
316 |
47% |
812 |
36% |
308 |
44% |
|
Current only clopidogrel |
202 |
9% |
51 |
8% |
165 |
7% |
45 |
6% |
|
Patients with diagnosis of bleeding before entry
|
|
|
|
|
|
|
|
|
|
Current clopidogrel and PPIs |
252 |
14% |
78 |
15% |
244 |
13% |
77 |
14% |
|
No current PPIs or clopidogrel |
659 |
37% |
154 |
29% |
702 |
39% |
164 |
30% |
|
Current only PPIs |
714 |
40% |
265 |
50% |
713 |
39% |
266 |
49% |
|
Current only clopidogrel |
154 |
9% |
38 |
7% |
158 |
9% |
40 |
7% |
| subtotal | 1779 | 535 | 1817 | 547 | ||||
*CVD cardiovascular disease; **AMI acute myocardial infarction; §PPIs proton-pump inhibitors.