Table 2. Population pharmacokinetic parameters of ciclosporin and bootstrap results (n=500).
| PK parameters | RSE (%) | Bootstrap |
|||
|---|---|---|---|---|---|
| Median | 2.5th | 97.5th | |||
| Absorption rate constant (h−1) Ka | 0.68 (Fixed) | - | 0.68 | ||
| Apparent volume of distribution (L) V/F V=θ1×(Bodyweight/70) | |||||
| θ1 | 178 | 31.4 | 171 | 100 | 331 |
| Apparent clearance (L/h) CL/F CL=θ2×(Bodyweight/70)0.75×RF×Fstanozolol | |||||
| θ2 | 31.5 | 18.8 | 30.9 | 21.6 | 42.8 |
| RF=1-(CREA/44)×θ3 | |||||
| θ3 | 0.0821 | 22.2 | 0.0802 | 0.0398 | 0.1139 |
| Fcomedication | 0.83 | 5.1 | 0.84 | 0.75 | 0.93 |
| Inter-individual variability (%) | |||||
| Ka | 58.5 | 59.1 | 59.5 | 19.6 | 95.8 |
| CL/F | 12.8 | 39.5 | 12.1 | 7.6 | 17.5 |
| Intra-individual variability (%) | |||||
| CL/F | 9.4 | 35.5 | 9.3 | 6.1 | 12.7 |
| Residual variability | |||||
| Proportional (%) | 22.4 | 20.0 | 22.0 | 17.8 | 26.7 |
| Additive (ng/mL) | 34.1 | 35.5 | 34.2 | 15.0 | 47.7 |
| RSE, relative standard error; RF, renal function; CREA, serum creatinine concentration (μmol/L). | |||||