Table 3. Population pharmacokinetic parameters of ciclosporin and bootstrap results (n=500). Values are expressed as mean (range).
| Stem cell transplant children9 | Renal transplant children8 | Renal pre-transplant children7 | Children with aplastic anemia (present study) | |
|---|---|---|---|---|
| Number of patients | 17 | 98 | 166 | 102 |
| Age (year) | 8.8 (1–16) | 9.7 (1.5–20.7) | 6.3 (0.36–17.5) | 8.8 (0.9–17.6) |
| Weight | 32.4 (13–58) | 35.2 (10.4–73.8) | 22.2 (6.9–64) | 31.3 (6.5–69.0) |
| CL/F (L/h) | 29.3 (F=38.6%) | 23.1 | 16.9 (F=36%) | 15.1 (3.8–27.5) |
| CL/F/WT (L·h−1·kg−1) | - | - | - | 0.45 (0.27–0.70) |
| V/F (L) | VC/F=42.7; VP/F=155.2 (F=38.6%) | VC/F=70.3; VP/F=200 | VC/F=14.7; VP1/F=54.4; VP2/F=12.2 (F=36%) | 89.1 (16.5–213.1) |
| V/F/WT (L/kg) | - | - | - | 2.54 |
VC, central volume of distribution; VP, peripheral volume of distribution; F, bioavailability.