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. Author manuscript; available in PMC: 2015 Jul 3.
Published in final edited form as: Prog Neuropsychopharmacol Biol Psychiatry. 2013 Oct 17;52:86–93. doi: 10.1016/j.pnpbp.2013.10.009

Fig. 2.

Fig. 2

Effect of insula inactivation on (a) nicotine- (.15 mg/kg SC, 10 min before the session) or (b) cue-induced reinstatement of nicotine seeking tests after extinction (n = 8 and n = 6, respectively). Data are expressed as means (±SEM) of the number of lever presses during baseline conditions (BL) and during sessions with infusion of vehicle (Veh insula) or the Bac/Mus mix in the insula (insula inact.) 5–10min before nicotine priming. *p<.05; **p<.01; ***p< .001 versus baseline; #p<.05; ##p< .01 versus vehicle infusion (Veh insula); Student–Newman–Keuls multiple comparison test after significant analysis of variance for repeated measures.