Table 1.
Ganetespib is more potent than 17-AAG in SCLC cell lines.
| Cell line | IC50 (Ganetespib) nM | IC50 (17-AAG) nM | Fold | P value |
|---|---|---|---|---|
| H82 | 30.27 | 3650 | 120.58 | <0.0001 |
| GLC4 | 20.47 | 40.6 | 1.98 | 0.0007 |
| H69 | 83.36 | 5800 | 117.08 | 0.0004 |
| H128 | 69.55 | 17 | 0.24 | 0.0115 |
| H146 | 28.51 | 1465 | 51.39 | 0.0004 |
| H187 | 24.99 | 163,800 | 6554.52 | 0.0013 |
| H526 | 21.64 | 2460 | 113.68 | 0.0023 |
| N592 | 14.12 | 18.5 | 1.31 | 0.1903 |
| H620 | 32.67 | 2455 | 75.15 | 0.0022 |
| H792 | 45.07 | 126 | 2.79 | 0.0013 |
| H1173 | 12.62 | 338 | 26.78 | 0.0001 |
| AC3 | 25.90 | 10,840 | 418.83 | <0.0001 |
|
| ||||
| Mean IC50 | 30.89 | 15971 | 193.30 | <0.0001* |
*
One-way ANOVA