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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: FEMS Microbiol Rev. 2013 Dec 19;38(3):493–522. doi: 10.1111/1574-6976.12050

Figure 10. A model for regulation of aerial hyphae formation by extracellular proteases, a protease inhibitor, and a peptide in S. coelicolor (Chater et al., 2010).

Figure 10

The adpA and 5913 genes contain TTA DNA sequences that specify UUA codons, which require the tRNA product of the bldA gene in order to be translated. 5913 is an extracellular protease that negatively regulates the protease inhibitor STI (Streptomyces trypsin inhibitor), which binds to and inhibits 1355, an extracellular protease proposed to cleave proproteins required for aerial hyphae formation. An unidentified peptide signal imported by BldK may induce expression of 5913, although this is speculative, as indicated by the question mark.