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. Author manuscript; available in PMC: 2015 May 1.
Published in final edited form as: FEMS Microbiol Rev. 2013 Dec 19;38(3):493–522. doi: 10.1111/1574-6976.12050

Figure 9. Generation of the C-signal (p17) in M. xanthus by a proteolytic cascade that incorporates destruction of a regulatory protein and regulation by compartmentalization.

Figure 9

The protease PopC and the substrate p25 are present in vegetative cells but PopC is held in a complex with PopD and not secreted. The PopC secretion system is not known and indicated by a grey barrel structure. In response to starvation, PopD is degraded in an FtsHD-dependent manner and PopC is secreted. Outside the cells, PopC cleaves p25 to generate p17 and is rapidly degraded. The question mark indicates that the protease(s) involved in PopC degradation is not known.